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●Purchase●Description(-)-JQ1istheinactivestereoisomerofthepotent,cell-permeable,smallmoleculebromodomaininhibitor(+)-JQ1thatcompetitivelybindstoacetyl-lysinerecognitionmotifs
聯(lián)系電話:
(-)-JQ1 is the inactive stereoisomer of the potent, cell-permeable, small molecule bromodomain inhibitor (+)-JQ1 that competitively binds to acetyl-lysine recognition motifs. (+)-JQ1 competitively binds to the bromodomain displacing the BRD4 fusion oncoprotein from chromatin, which induces squamous differentiation and specific anti-proliferative effect in BRD4-dependent cell lines and patient-derived xenograft models. However, study results have shown that (-)-JQ1 fails to significantly interact with any bromodomain tested and exhibits inhibition against BRD4(1) with and IC50 of 10,000 nM.
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