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STAT5 Luciferase Reporter U937 Cell Line

  • 產(chǎn)品型號:79941
  • 廠商性質(zhì):生產(chǎn)廠家
  • 更新時間:2023-11-11
  • 訪  問  量:176
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Description

The STAT5 (Signal transducer and activator of transcription 5) Luciferase Reporter U937 cell line monitors STAT5-mediated signal transduction pathways in the human monocyte cell line U937. It contains a firefly luciferase gene driven by STAT5 response elements located upstream of the minimal TATA promoter. After activation by GM-CSF (Granulocyte-macrophage colony-stimulating factor), the endogenous transcription factor STAT5 binds to the response elements, inducing transcription of the luciferase reporter gene.

These cells respond to GM-CSF. Functional validation experiments showed that GM-CSF-induced luciferase activity was inhibited by anti-GM-CSF neutralizing antibody (Clone #BVD2-21C11).

Figure 1: Illustration of STAT5 Luciferase Reporter U937 Cell Line mechanism of action.
Created with BioRender.com

Purchase of this cell line is for research purposes only; commercial use requires a separate license. View the full terms and conditions.

Synonyms
Signal Transducer And Activator Of Transcription 5A cell line, MGF cells, U937 Reporter
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