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PD-L1 / TCR Activator - CHO Recombinant Cell Line

●Purchase●DescriptionRecombinantCHO-K1cellsconstitutivelyexpressinghumanPD-L1(ProgrammedCellDeath1Ligand1

  • 產(chǎn)品型號(hào):60536
  • 廠商性質(zhì):生產(chǎn)廠家
  • 更新時(shí)間:2023-11-11
  • 訪  問(wèn)  量:353
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Description

Recombinant CHO-K1 cells constitutively expressing human PD-L1 (Programmed Cell Death 1 Ligand 1, CD274, B7 homolog 1 (B7- H1), GenBank accession # NM_014143) and an engineered T cell receptor (TCR) activator. This cell lines was functionally validated in a cell-based assay.

PD-L1 CHO Cell Line TCR Activator BPS Bioscience

Figure 1: Mechanism of action of TCR activator/ PD-L1 CHO Cell Line in combination with PD-1/NFAT reporter-Jurkat cell line. Jurkat T cells expressing NFAT reporter with constitutive expression of PD-1 (PD-1/NFAT Reporter Jurkat Cell Line, BPS Bioscience #60535) act as effector cells. When co-c*ted, TCR complexes on PD-1/NFAT Reporter Jurkat cells are activated by the TCR activator of TCR Activator/ PD-L1– CHO Recombinant Cell Line, resulting in expression of the NFAT luciferase reporter. However, PD-1 and PD-L1 ligation prevents TCR activation and suppresses the NFAT-responsive luciferase activity. This inhibition can be specifically reversed by anti-mouse PD-1 or anti-mouse PD-L1 antibodies. PD-1/PD-L1 neutralizing antibodies block PD-1:PD-L1 interaction and promote T cell activation, resulting in reactivation of the NFAT responsive luciferase reporter.

This product has been cited 11 times.

Purchase of this cell line is for research purposes only; commercial use requires a separate license. View the full terms and conditions.

Synonyms
Programmed Cell Death 1 Ligand 1, PDL1, PD-L1, B7 homolog 1, B7H1, B7-H1, CD274, PDCD1L1
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