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PD-1/IL-2 Luciferase Reporter Jurkat Cell Line

●Purchase●DescriptionPD-1/IL-2LuciferaseReporterJurkatCellLineisaJurkatTcelllineconstitutivelyexpressinghumanPD-1(ProgrammedCellDeath1

  • 產(chǎn)品型號(hào):82117
  • 廠商性質(zhì):生產(chǎn)廠家
  • 更新時(shí)間:2023-11-11
  • 訪  問  量:182
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Description

PD-1/IL-2 Luciferase Reporter Jurkat Cell Line is a Jurkat T cell line constitutively expressing human PD-1 (Programmed Cell Death 1, also known as PDCD1, SLEB2, CD279, GenBank Accession #NM_005018), and conditionally expressing firefly luciferase under the control of a human interleukin-2 (IL-2) promoter. This cell line has been validated by flow cytometry for expression of PD-1, and in co-culture assays that assess the PD-L1/PD-1 interaction on Jurkat T cell activation.

Figure 1: Illustration of the mechanism of action of PD-1/IL-2 Luciferase Reporter Jurkat Cell Line in a co-culture assay.
The TCR activator presented at the surface of PD-L1/TCR Activator CHO cells stimulates TCR (T cell receptor) in Jurkat T cells, whereas overexpression of PD-L1 on the CHO cell line engages Jurkat PD-1 resulting in blocking TCR signaling and preventing activation of the IL-2 promoter. Addition of a neutralizing anti-PD-1 or anti-PD-L1 antibody to the co-culture prevents formation of the PD-L1/PD-1 complex, and results in TCR activation and increased IL-2 promoter activity, which translates into increased luciferase reporter signal.

Purchase of this cell line is for research purposes only; commercial use requires a separate license. View the full terms and conditions.

Synonyms
Programmed cell death protein 1, Protein PD-1, hPD-1, CD279, PDCD1, PD1, Interleukin-2, T-cell growth factor (TCGF), Aldesleukin, IL2
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