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AP-1 Reporter – HEK293 Recombinant Cell Line (JNK signaling pathway)

●Purchase●DescriptionThestress-activatedproteinkinase/c-JunN-terminalkinase(SAPK/JNK)familyofproteinsincludesmitogen-activatedproteinkinases(MAPKs)thatareactivatedbystress

  • 產(chǎn)品型號:60405
  • 廠商性質(zhì):生產(chǎn)廠家
  • 更新時間:2023-11-11
  • 訪  問  量:293
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Description

The stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) family of proteins includes mitogen-activated protein kinases (MAPKs) that are activated by stress, inflammatory cytokines, mitogens, oncogenes, and inducers of cell differentiation and morphogenesis. Upon activation of the SAPK/JNK pathway, MAP Kinase Kinases phosphorylate and activate JNKs. The activated JNKs translocate to the nucleus where they phosphorylate and activate transcription factors such as c-Jun. c-Jun then binds to the activator protein-1 (AP1) response element and induces AP1 transcription.

The AP1 Reporter – HEK293 cell line contains a firefly luciferase gene under the control of AP1-responsive elements that are stably integrated into HEK293 cells. This cell line is validated for its response to stimulation by Phorbol 12-Myristate 13-Acetate (PMA) and to treatment with inhibitors of the JNK signaling pathway.

This product has been cited 2 times.

Purchase of this cell line is for research purposes only; commercial use requires a separate license. View the full terms and conditions.

Synonyms
JNK reporter, AP-1 cell line, activator protein-1 cell line, activator protein-1
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