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Anti-Mesothelin CAR-T Cells

  • 產(chǎn)品型號(hào):78729
  • 廠商性質(zhì):生產(chǎn)廠家
  • 更新時(shí)間:2023-11-11
  • 訪  問(wèn)  量:280
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Description

The Anti-mesothelin CAR-T cells are produced by high-titer lentiviral transduction of human primary CD4+CD8+ T cells using the anti-Mesothelin CAR Lentivirus (Mesothelin ScFv-CD8-4-1BB-CD3ζ; BPS Bioscience #78703). These ready-to use CAR-T cells express an anti-Mesothelin CAR consisting of the scFv (Single chain fragment variable) of anti-Mesothelin (clone P4) linked to a 2nd generation CAR (Chimeric Antigen Receptor) containing CD8 hinge and transmembrane domains, and the 4-1BB and CD3ζ signaling domains (Figure 1).

These CAR-T cells have been validated using flow cytometry (to determine the CAR expression) and co-culture cytotoxicity assays.

Figure 1: Construct diagram showing components of the anti-Mesothelin CAR expressed in anti-Mesothelin CAR-T cells.

Synonyms
CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, Megakaryocyte-potentiating factor (MPF), MSLN, MPF, SMRP
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