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IL-6:IL-6R Inhibitor Screening Assay Kit

●Purchase●DescriptionInterleukin6(IL-6),anditsreceptorcomplexinterleukin6receptor(IL-6R,CD126)-gp130(CD130),playanimportantroleinimmuneresponse

  • 產(chǎn)品型號(hào):78027
  • 廠商性質(zhì):生產(chǎn)廠家
  • 更新時(shí)間:2023-11-12
  • 訪  問(wèn)  量:204
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Description

Interleukin 6 (IL-6), and its receptor complex interleukin 6 receptor (IL-6R, CD126)-gp130 (CD130), play an important role in immune response. Elevated IL-6 leads to an acute severe systemic inflammatory response known as ‘cytokine storm’, where an uncontrolled and excessive release of pro-inflammatory cytokines can cause multisystem organ failure and death. Mortality in patients has been linked to this severe response induced by the virus. Tocilizumab is a humanized monoclonal antibody against the IL-6R used as immunosuppressive drug, and it is emerging as an alternative treatment for patients at risk for ‘cytokine storm’.


The IL-6:IL-6R Inhibitor Screening Assay Kit is designed for screening and profiling inhibitors of this receptor-ligand interaction. The key to this kit is the high sensitivity of detection of IL-6-Biotin protein by Streptavidin-HRP. Only a few simple steps on a microtiter plate are required for the assay. First, IL-6R protein is attached to a nickel-coated 96-well plate. Next, IL-6-Biotin incubated with IL-6R on the plate. Finally, the plate is treated with Streptavidin-HRP followed by addition of an HRP substrate to produce chemiluminescence, which then can be measured using a chemiluminescence reader.

IL-6R Inhibitor Screening Assay Kit

Synonyms
Interleukin 6 kit, IL6R inhibitor screening, IL6 kit, interleukin 6 receptor inhibitor screening, cytokine assay, IL-6-Biotin
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