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BRAF (V600E) Kinase Assay Kit

●Purchase●DescriptionB-raf,afterstimulationbyactivatedRAS,phosphorylatesMEK1resultinginactivationofthemitogen-activatedprotein(MAP)kinasecascade

  • 產(chǎn)品型號(hào):48688
  • 廠商性質(zhì):生產(chǎn)廠家
  • 更新時(shí)間:2024-01-31
  • 訪  問(wèn)  量:221
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Description

B-raf, after stimulation by activated RAS, phosphorylates MEK1 resulting in activation of the mitogen-activated protein (MAP) kinase cascade. Since the MAPK cascade has been shown to be a critical factor in melanoma development, it has been proposed that targeting B-raf could be a promising approach to combat melanoma. More importantly, 40-60% of melanomas display a mutation in BRAF, e.g. B-Raf(V600E), which leads to constitutive activation of the MAP kinase pathway. The B-Raf(V600E) Kinase Assay Kit is designed to measure B-Raf(V600E) kinase activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent. In addition, the B-Raf(V600E) Kinase Assay Kit includes wild type B-Raf enzyme as a positive control for researchers investigating B-Raf(V600E) specific inhibitors.

This product has been cited 8 times.

Synonyms
BRAF1, RAFB1, B-raf 1, MGC126806, MGC138284, BRAF (V600E)
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