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BPS Bioscience去乙?;窰DAC/Sirtuin篩選和檢測服務

Histonedeacetylases(HDACs)arenegativeregulatorsofgenetranscriptionduetotheirabilitytotightlycompactheterochromatinbyremovingacetylgroupsfromhistonetails

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  • 廠商性質:生產廠家
  • 更新時間:2023-12-19
  • 訪  問  量:275
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詳細介紹

Histone deacetylases (HDACs) are negative regulators of gene transcription due to their ability to tightly compact heterochromatin by removing acetyl groups from histone tails. Thus, they are considered important targets for anti-cancer therapeutics due to their involvement in cell cycle regulation, cell proliferation, and apoptosis, and overall gene expression. Similarly, the Sirtuin family of deacetylases are targets across a number of therapeutic areas, including cancer, inflammation, and neurodegenerative diseases.

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Biochemical Assay Format:

This assay method eliminates dealing with the radioactivity, extraction, and chromatography aspects of other assays. Only two simple steps on a microtiter plate are needed to analyze HDAC activity. First, an HDAC fluorometric substrate is incubated with purified HDAC enzyme. HDAC deacetylation sensitizes the resulting product to subsequent treatment with the developer, which releases a fluorophore that is easily measured on a fluorescence reader. The result is a robust signal that enables sensitive testing of inhibitors.

We offer one of the most extensive suite of HDAC and Sirtuin targets on the market for screening and profiling services. Our team of experts, using our in-house developed biochemical assay kits, can provide:

  • Screening for inhibitor activity and selectivity across our full panel or just your targets of interest

  • Determination of IC50

  • Project guidance and questions answered in a timely manner

  • Delivery of detailed results promptly and on time

If follow-up studies are required, we can provide the same active proteins as the ones used in our assays.

Available Service Assays

HDAC 1 (Human)

(Mouse)

HDAC 6 (Human)

(Mouse)

HDAC 9SIRT 1
HDAC 2HDAC6 (H216A)HDAC 11SIRT 2
HDAC 3HDAC6 (H611A) SIRT 3
HDAC 4HDAC 7 SIRT 5
HDAC 5HDAC 8 SIRT6

如果您需要了解更多關于我們的服務的信息,請聯(lián)系info。

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