www亚洲午夜人美精片V区,国产精品乱码一区二区,亚洲另类黑,亚洲AV天天

熱門搜索: 50072ATAT1, GST-tag Recombinant 40520ATF2, GST-Tag Recombinant 31114GCN5 (727-837), His-tag Recombinant 50074GCN5 (KAT2A), FLAG-tag Recombinant 50071p300 (KAT3B), His-GST-tag Recombinant 11004ACHE, His-Tag Recombinant 50272BCL-2, His-Tag Recombinant 100077BCL2A1, His-Tag Recombinant 100080BCL2L10, His-Tag Recombinant 100091BCL2L2, His-Tag Recombinant 80113Caspase6, His-tag Recombinant 70000Caspase7, His-tag Recombinant 80114Caspase8, His-tag Recombinant 100543GPX4, FLAG-Tag Recombinant 100054MALT1, FLAG-Tag (Mouse) Recombinant 100637MCL-1 His-Tag (Mouse) Recombinant

產品展示/ Product display

您的位置:首頁  /  產品展示  /  技術服務  /  檢測相關  /  BPS Bioscience的PROTAC和蛋白質降解研究服務

BPS Bioscience的PROTAC和蛋白質降解研究服務

服務名稱:PROTAC和蛋白質降解研究服務BPSBioscienceisaleading productmanufacturer andserviceproviderinthePROTACspace

  • 產品型號:
  • 廠商性質:生產廠家
  • 更新時間:2023-12-19
  • 訪  問  量:269
立即咨詢

聯(lián)系電話:

詳細介紹
  • 服務名稱:

    PROTAC和蛋白質降解研究服務

BPS Bioscience is a leading product manufacturer and service provider in the PROTAC space. Using our services, we can design and conduct homogeneous proximity assays to assess the chemical adaptor function of PROTACs.

BPS Bioscience has designed many assays to measure and study

  • Cereblon Binding

  • Cereblon Ubiquitination

  • PROTAC Optimization for BET Bromodomain-Cereblon Binding

  • PROTAC Optimization for BET Bromodomain-Von Hippel Lindau (VHL) Binding

  • PROTAC Optimization for CDK Kinase-Cereblon Binding

In addition to our existing assay portfolio, we have the capabilities to develop custom PROTAC and Protein Degradation assays specialized for your project details. Please contact us to learn more.

Example Assay

圖片

The PROTAC Optimization Assay for BET Bromodomain-Cereblon Binding is designed for testing and profiling of PROTACs directed against BET Bromodomain family and Cereblon complex. Cereblon (CRBN) is a Substrate recognition component of a DCX (DDB1-CUL44-Rbx1 ) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

With this assay, only three simple steps on a microtiter plate are required for PROTAC activity detection. First, a sample containing PROTAC is incubated with CRBN and BRD3(BD2), one of BET bromodomains. Next, acceptor beads are added, then donor beads, followed by reading the Alpha-counts.

圖片Inhibition by (+)-JQ1 (BPS Bioscience #27401) or Pomalidomide of dBET1-mediated interaction of Cereblon with BRD3(BD2), measured using the PROTAC Optimization Kit for BET Bromodomain Cereblon Binding, BPS Bioscience #79770.

PROTACs ®

Targeted protein degradation using Proteolysis Targeting Chimeras, or PROTAC , is a new and promising therapeutic method in drug discovery. PROTACs have the ability to regulate protein degradation through targeted control of ubiquitin E3 ligases. This novel technology allows for the degradation of disease-related proteins and offers many advantages over traditional protein inhibition.

圖片

PROTACs function by hijacking the final action of E3 ligases and subsequently tagging the protein of interest for ubiquitination. A PROTAC is composed of three parts; an E3 ligand that binds to an E3 ligase, a ligand that binds to the protein of interest, and a linker connecting the two ligands. When each ligand binds its respective partner, it triggers ubiquitination of the protein of interest. The PROTAC itself is not degraded by this process, making PROTACs a valuable tool for mediating protein degradation. A single PROTAC can promote the degradation of many subsequent proteins and functions substoichiometrically.

Advantages

  • Promotes degradation that circumvents the native resistance of proteins against sustained inhibition

  • Select weak binding and promiscuous ligands can be utilized with PROTACs and still demonstrate high degradation efficacy

  • Ineffectual ligands which do not modulate the cellular functions of the protein of interest can be used to mediate degradation through PROTACs

  • PROTACs could have the ability to degrade proteins previously believed to be 'undruggable' through conventional small molecule inhibition

PROTAC ® is a registered trademark of Arvinas Operations Inc., and is used under license

如果您需要了解更多關于我們的服務的信息,請聯(lián)系info。

留言詢價

留言框

  • 產品:

  • 您的單位:

  • 您的姓名:

  • 聯(lián)系電話:

  • 常用郵箱:

  • 省份:

  • 詳細地址:

  • 補充說明:

  • 驗證碼:

    請輸入計算結果(填寫阿拉伯數字),如:三加四=7
關注公眾號

郵箱:infocn@bpsbioscience.com

傳真:

地址:上海靜安區(qū)

Copyright © 2025 BPS Bioscience Inc.版權所有   備案號:   技術支持:化工儀器網

TEL:

掃碼加微信